T9262
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T9262
Sigma
Tamoxifen citrate salt
≥99%
| Synonym: | (Z)-1-(p-Dimethylaminoethoxyphenyl)-1,2-diphenyl-1-butene |
| CAS Number: | 54965-24-1 |
| Linear Formula: | C26H29NO · C6H8O7 |
| Molecular Weight: | 563.64 |
| EC Number: | 259-415-2 |
| MDL number: | MFCD00058321 |
| PubChem Substance ID: | 24278059 |
Description
| Biochem/physiol Actions | Protein kinase C inhibitor. Induces apoptosis in human malignant glioma cell lines. Tamoxifen and its metabolite 4-hydroxytamoxifen are selective estrogen response modifiers (SERMs) that act as estrogen antagonists in mammary gland. Blocks estradiol-stimulated VEGF production in breast tumor cells. |
Properties
| assay | ≥99% |
| Gene Information | human ... PRKCA(5578), PRKCB(5579), PRKCD(5580), PRKCE(5581), PRKCG(5582), PRKCH(5583), PRKCI(5584) |
| storage temp. | 2-8°C |
Safety
| Personal Protective Equipment | Eyeshields, Gloves, type P2 (EN 143) respirator cartridges |
| Hazard Codes | T |
| Risk Statements | 45-60-61-22-64 |
| Safety Statements | 53-36/37/39-45 |
| WGK Germany | 3 |
| RTECS | KH2387000 |
References
| reference | Issandou, M., et al., Opposite effects of tamoxifen on in vitro protein kinase C activity and endogenous protein phosphorylation in intact MCF-7 cells. Cancer Res. 50, 5845-5850, (1990) |
| O'Brian, C.A., et al., Inhibition of protein kinase C by tamoxifen. Cancer Res. 45, 2462-2465, (1985) | |
| Gold, E., et al., Tamoxifen and norethisterone: effects on plasma cholesterol and total body calcium content in the estrogen-deficient rat. Horm. Metab. Res. 26, 100-103, (1994) | |
| Powis, G., Signalling targets for anticancer drug development. Trends Pharmacol. Sci. 12, 188-194, (1991) | |
| Takei, H., et al., , In vitro regulation of vascular endothelial growth factor by estrogens and antiestrogens in estrogen-receptor positive breast cancer. Breast Cancer 9, 39-42, (2002) | |
| Schwartz, Z., et al., Tamoxifen elicits its anti-estrogen effects in growth plate chondrocytes by inhibiting protein kinase C. J. Steroid Biochem. Mol. Biol. 80, 401-410, (2002) |
